FAUCI DIARY ARCHIVE — Thursday, September 19, 2013
https://faucisdiary.com/diary/2013-09-19

Text below is verbatim from the released PDFs, with the original line breaks.
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DIARY ENTRY — Thursday, September 19, 2013
Source: Diary Prequel, p. 323 of 2026.07.27_Diary-Prequel-.pdf
Words: 208
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I called an important Summit that took place at Bethesda North
Marriott. Purpose was to discuss the advisability of using Adenovirus vectors for HIv
vaccines given the failures of Ad5 vectors in 3 vaccine trials, but more importantly the
fact that there were “trends” in each study that showed an enhancing effect on acquisition
of infection in the vaccines who received the Ad5 vector. Meta-analysis of the 3 studies
showed a significant (<0.01) 32% enhancement of infection. Big question is that there
are ongoing plans to use other vectors (Ad26, among others) in future HIV vaccine trials
as well as in non-HIV vaccine trials (malaria, TB, etc.) in populations that might be at
risk for HIV. Seems to me that any vaccine that activates cells that might migrate to the
mucosal surface can have an enhancing effect that is seen if the vaccine is not efficacious.
If the vaccine is efficacious, then the enhancing effect is masked as might have been the
case with the 31% efficacy of the RV144 trial. Important issue is to try to get the
efficacious vaccine and not do a trial on an Ad vector unless it shows an immune
response that would be better than any other vaccines that we have tried.