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Drew: Thanks for sending this. Looks like you have touched all the bases of informing people of your results. It would be interesting to see what human dose levels given IM do. I hope that all is well with you. Congratulations on the Rosenstiel Award! Best regards, Tami Noam Project Coordinator Dan David Prize Office: @tauex.tau.ac.ilEmail: www.dandavidprize.orgWebsite: From: Conrad, Patricia (NIH/NIAID) [E] < @niaid.nih.gov> Sent: Tuesday, March 16, 2021 1:55 PM To: Charlotte Halle < @tauex.tau.ac.il> Cc: Dan David Prize < @tauex.tau.ac.il>; Barasch, Kimberly (NIH/NIAID) [E] < @nih.gov>; Awwad, David (NIH/NIAID) [C] < @niaid.nih.gov>; Folkers, Greg (NIH/NIAID) [E] < @niaid.nih.gov> Subject: RE: Quick request re Dan David Prize Please fed ex to the address below to the Attention of Kim Barasch as Dr. Fauci’s mail is delayed. I will ask Kim – cc’d here to track its arrival and make sure we send you an iphone picture when it arrives. Thank you. National Institute of Allergy and Infectious Diseases The National Institutes of Health Bethesda, Maryland office From: Charlotte Halle < @tauex.tau.ac.il> Sent: Tuesday, March 16, 2021 7:45 AM To: Conrad, Patricia (NIH/NIAID) [E] < @niaid.nih.gov> Cc: Dan David Prize < @tauex.tau.ac.il> Subject: Quick request re Dan David Prize Dear Patti, We are preparing a framed certificate and getting ready to mail it to Dr. Fauci. (We are hoping to get a photo or film of him holding the certificate, which we would use to represent him receiving the award during our online ceremony in May.) Please provide the postal address where it would be most convenient for him to receive this certificate. Many thanks, Charlotte Charlotte Hallé Director Dan David Prize Office: Mobile: Email: @tauex.tau.ac.il Released by Chairman Rand Paul Website: www.dandavidprize.org

FYSA I will review with Barney, Karin and Julie at VRC to get some input of what this may mean. From: Fauci, Anthony (NIH/NIAID) [E] < @niaid.nih.gov> Sent: Monday, March 1, 2021 6:07 PM To: Mascola, John (NIH/VRC) [E] < @mail.nih.gov> Cc: Lane, Cliff (NIH/NIAID) [E] < @niaid.nih.gov> Subject: FW: - Let us discuss. Anthony S. Fauci, MD Director National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda, MD Phone: FAX: E-mail: @niaid.nih.gov The information in this e-mail and any of its attachments is confidential and may contain sensitive information. It should not be used by anyone who is not the original intended recipient. If you have received this e-mail in error please inform the sender and delete it from your mailbox or any other storage devices. The National Institute of Allergy and Infectious Diseases (NIAID) shall not accept liability for any statements made that are the sender's own and not expressly made on behalf of the NIAID by one of its representatives. From: Weissman, Drew < @pennmedicine.upenn.edu> Sent: Monday, March 1, 2021 5:21 PM To: Fauci, Anthony (NIH/NIAID) [E] < @niaid.nih.gov> Subject: Re: - Tony, Here is the human dose IM studies in pregnant mice. We still have some concern over the data and are talking to all of the appropriate people. Congratulations on the Dan David Prize Hope you and your family are doing well.

FYI. We should each review and then discuss. Thanks, John From: Fauci, Anthony (NIH/NIAID) [E] < @niaid.nih.gov> Sent: Monday, March 1, 2021 6:07 PM To: Mascola, John (NIH/VRC) [E] < @mail.nih.gov> Cc: Lane, Cliff (NIH/NIAID) [E] < @niaid.nih.gov> Subject: FW: - Let us discuss. Anthony S. Fauci, MD Director National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda, MD Phone: FAX: E-mail: @niaid.nih.gov The information in this e-mail and any of its attachments is confidential and may contain sensitive information. It should not be used by anyone who is not the original intended recipient. If you have received this e-mail in error please inform the sender and delete it from your mailbox or any other storage devices. The National Institute of Allergy and Infectious Diseases (NIAID) shall not accept liability for any statements made that are the sender's own and not expressly made on behalf of the NIAID by one of its representatives. From: Weissman, Drew < @pennmedicine.upenn.edu> Sent: Monday, March 1, 2021 5:21 PM To: Fauci, Anthony (NIH/NIAID) [E] < @niaid.nih.gov> Subject: Re: - Tony, Here is the human dose IM studies in pregnant mice. We still have some concern over the data and are talking to all of the appropriate people. Philadelphia, PA Released by Chairman Rand Paul

Thanks Karin. I don’t know what Drew Weismann is trying to accomplish with this. Ultimately this is an FDA decision. From: Bok, Karin (NIH/VRC) [E] < @nih.gov> Sent: Tuesday, March 2, 2021 8:51 AM To: Erbelding, Emily (NIH/NIAID) [E] < @nih.gov> Subject: FW: - I am sure you are also dealing with this, my answer to John below if helpful. Karin John, Thank you for sharing. I have no comments or concerns about this study, this is typically what you would see in mice with other types of vaccines as well, and it makes sense that mRNA is present in other sites as well, including placenta, etc. As a side note, I was part of the deliberation with CDC (ACIP/ACOG) that led to the permissive recommendation in pregnancy, and the assumptions from the authors below are very incorrect: Assumption that all of mRNA-LNP degraded at injection site Balancing perhaps differential risk/benefit ratio for maternal health vs fetal health The SMEs on that call (especially obgyns) were aware that mRNA might reach the fetus. The only discussion was around the possibility of that mRNA to integrate into the nuclear DNA. And the second main concern was the fever caused by the vaccine, especially during the first trimester, but they went around that by recommending the administration of acetaminophen after vaccination. Needless to say both mom and baby’s health are important. CDC recently provided a nice overview of the over 30,000 pregnant women who have been vaccinated so far, with more than 200 deliveries with no safety concerns. All vaccines administered to pregnant women historically have been found safe for mother and baby, so when we recently discussed pregnancy and the J&J vaccine, there was no concern, they recommended its use also unanimously. Let me know if you would like us (Emily, myself) to get a second opinion from the obgyns in the special populations working group (mainly Rich Beigi and Flor Muñoz) Thanks! Karin. Karin Bok, MS, PhD Senior Advisor, Vaccine Development Office of the Director, Vaccine Research Center National Institute of Allergy and Infectious Diseases National Institutes of Health phone: | mobile: Released | email: by Chairman @nih.gov Rand Paul https://www.niaid.nih.gov/about/vrc

Francis: I texted you to call me last night, but it was probably too late. Please give me a call about this at your convenience. Thanks, Tony From: Fauci, Anthony (NIH/NIAID) [E] Sent: Monday, March 15, 2021 9:35 PM To: Erbelding, Emily (NIH/NIAID) [E] < @nih.gov> Subject: FW: - Here are the Weissman data. From: Weissman, Drew < @pennmedicine.upenn.edu> Sent: Monday, March 1, 2021 5:21 PM To: Fauci, Anthony (NIH/NIAID) [E] < @niaid.nih.gov> Subject: Re: - Tony, Here is the human dose IM studies in pregnant mice. We still have some concern over the data and are talking to all of the appropriate people. Congratulations on the Dan David Prize Hope you and your family are doing well. Take care. Drew