FAUCI ARCHIVE — EMAIL THREAD: NHPs at IRF and DMID collaboration
https://faucisdiary.com/correspondence/nhps-at-irf-and-dmid-collaboration
1 message, Mar 28, 2020

Text below is verbatim from the released PDFs, with the original line breaks.
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Subject: NHPs at IRF and DMID collaboration
From: Emily Erbelding
To: Connie Schmaljohn
Cc: Cristina Cassetti, Paula Bryant, Judith Hewitt
Sent: Sat, 28 Mar 2020 09:01:57 -0400
Source: Reading Room, p. 386 of Reading-Room-FINAL.pdf
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Connie,
I learned yesterday that investigators on the IRF team weren't clear that the early NHP experiments done in
collaboration with David O'Connor were related to the Moderna mRNA vaccine. If you didn't know this, it is a
critical failure in communication on our part and we need to immediately address it.

We think that the rate-limiting step in taking the Moderna vaccine into Ph2 trials by May/June, will be proving
to the FDA that vaccine related enhancement won't be an added risk to participants. So starting these
experiments at a basic level (and not doing refined natural history studies first) is NIAID's highest priority for
these animals. I believe that Barney Graham has started doing the experiments in Ralph Baric's mouse model.
The FDA has signaled that data from a second species of animals will be necessary.

There wasn't time in the division directors meeting yesterday to get to this item on the agenda so I wanted to
follow up now.

To reiterate--getting the Moderna vaccine into Phase 2 trials is the highest priority for the vaccine effort (Quote
from Tony Fauci to me this week: "I hope that you feel like my foot is on your neck right now to get this done.")

Let me know if you want to discuss further.

regards,
Emily

Emily Erbelding, M.D., M.P.H.

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